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[不同病因心包炎时心脏的血管与淋巴管]

[Blood and lymph vessels of the heart in pericarditis of different etiology].

作者信息

Kalachev G A

出版信息

Kardiologiia. 1976 Nov;16(11):51-6.

PMID:1011467
Abstract

56 heart specimens with pericarditis of different etiology were studied (uraemic, tuberculous, bacterial). In the majority of cases pericarditis was a complication of rheumatic heart diseases, fibrous-cavernous tuberculosis and chronic nonspecific pulmonary lesions, cardiac tumours and other pathology. Models of uraemic and purulent pericarditis were created in 5 rabbits and 30 dogs. The methods of venous injections and cardiac blood vessels injections, angioradiography, macro- and microscopy, histology, electrocardiography were employed. The function of the lymphatic system of the heart was determined by studying dynamically the resorption of Polyglukin from the pericardial cavity of the experimental animals. It was established that the disorders in cardiac activity in cases of pericarditis largely depend on the involvement of its vessels, primarily of the cardiac microcirculation bed, as well as of the veins and lymph vessels ensuring the drainage of the myocardium. Blocks of the venous and lymphatic beds of the epicardium in acute bacterial pericarditis causes disorders in blood and lymph circulation in the superficial layers of the heart muscle. Oedema and hypoxia developing in such situations favour the transit of the process into a chronic one with the formation of adhesions of the serous sheaths of the heart. The complication of any disease by bacterial pericarditis, especially with the development of pericardial obliteration, should be considered as an unfavourable factor worsening the prognosis. Aseptic pericarditis is accompanied by insignificant changes in the vascular system of the heart and cause important disorders in the blood and lymph circulation only in cases of constrictive pericarditis formation.

摘要

对56份不同病因(尿毒症性、结核性、细菌性)的心包炎心脏标本进行了研究。在大多数病例中,心包炎是风湿性心脏病、纤维空洞型肺结核、慢性非特异性肺部病变、心脏肿瘤及其他病变的并发症。在5只兔子和30只狗身上建立了尿毒症性和化脓性心包炎模型。采用静脉注射、心脏血管注射、血管造影、大体和显微镜检查、组织学、心电图等方法。通过动态研究实验动物心包腔内聚明胶肽的吸收情况来确定心脏淋巴系统的功能。已证实,心包炎病例中心脏活动的紊乱很大程度上取决于其血管的受累情况,主要是心脏微循环床以及确保心肌引流的静脉和淋巴管。急性细菌性心包炎时心外膜静脉和淋巴床的阻塞会导致心肌表层血液和淋巴循环紊乱。这种情况下出现的水肿和缺氧有利于病情发展为慢性,形成心脏浆膜鞘的粘连。任何疾病并发细菌性心包炎,尤其是出现心包粘连时,都应被视为恶化预后的不利因素。无菌性心包炎仅在形成缩窄性心包炎时才会伴有心脏血管系统的轻微变化,并导致血液和淋巴循环的重要紊乱。

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