Fetisova T V, Frol'kis R A, Tsiomik V A, Smirnova I P, Likhtenshteĭn I E
Kardiologiia. 1976 Dec;16(12):110-6.
In 150 canine experiments it has been established that in myocardial infarction the activity of heart muscle enzymes decreases significantly and persistently in the zone of necrosis, moderately and reversibly--beyond this zone, individual enzymes being unequally sensitive to the effects of the given injuring factor. The shifts in the activity of the serum and heart muscle enzymes correlate only in the early days following the reproduction of the pathological state, while the levelling of hyperenzymia is accompanied by an enhancement of the enzymatic disorders in the myocardium in cases of infarction.
在150例犬类实验中已证实，在心肌梗死时，坏死区域心肌酶活性显著且持续降低，而在该区域之外则呈中度且可逆性变化，个别酶对特定损伤因素的影响敏感度不同。血清和心肌酶活性的变化仅在病理状态重现后的早期存在相关性，而在梗死病例中，酶血症的消退伴随着心肌酶紊乱的加剧。
