Fetisova T V, Smirnova I P
Ukr Biokhim Zh. 1977 Jan-Feb;49(1):107-12.
Heparin administered at the initial stage of myocardium infarction is shown to prevent a number of shifts in the metabolism of protein and polynucleotides of the injured heart. It does not promote the development of some changes, but intensifies only a few of those evoked by the ligation of coronary artery in the myocardium nitrogen metabolism. The preparation inhibitory effects are also slightly pronounced in the normal myocardium where the preparation activates many metabolic reactions of nitrogen-containing biopolymers. Inactivation of enzymatic systems in a cell is likely to be not the basic, as some researchers consider, but one of the secondary mechanisms of heparin incorporation into metabolism proceeding in normal and pathologically changed tissues.
在心肌梗死初期给予肝素，可防止受损心脏蛋白质和多核苷酸代谢发生一系列变化。它不会促进某些变化的发展，而仅会增强心肌氮代谢中冠状动脉结扎所引发的少数变化。在正常心肌中，该制剂的抑制作用也不太明显，而在正常心肌中该制剂会激活含氮生物聚合物的许多代谢反应。细胞内酶系统的失活可能并非如一些研究人员所认为的那样是基本机制，而是肝素参与正常和病理变化组织中代谢过程的次要机制之一。
