Liberman T Iu
Kardiologiia. 1976 Aug;16(8):43-8.
Clinical and laboratory observations were conducted using a new Soviet-made drug Pterophene as a diuretic in 30 patients with circulatory insufficiency. Stage IIB and III. Pterophene was found to produce a distinct natriuretuc and diuretic effect. With its daily intake, the effect has a prompt onset, it increases by the 3rd-4th day of therapy, persists for a long period, slightly decreasing in its potency by the 7th-10th day of its continuous administration. A valuable property of Pterophene is its potassium-retaining effect. The drug is well tolerated by the patients, and it can be combined with other diuretics. Pherophene potentiates the diuretic and natriuretic effect of Hypothiaside, Furosemide and Nuvorite, and decreases potassium excretion that was enhanced by these drugs.
使用苏联产新药蝶啶作为利尿剂,对30例循环功能不全IIB期和III期患者进行了临床和实验室观察。发现蝶啶有明显的利钠和利尿作用。每日服用该药,起效迅速,治疗第3 - 4天作用增强,作用持续时间长,连续给药第7 - 10天效力略有下降。蝶啶的一个重要特性是其保钾作用。患者对该药耐受性良好,可与其他利尿剂合用。蝶啶可增强氢氯噻嗪、呋塞米和氯噻酮的利尿和利钠作用,并减少这些药物所增强的钾排泄。