Kudrin A N, Zhdanova N F
Kardiologiia. 1976 Sep;16(9):105-11.
The application of acetylcholine to the atria of an isolated heart of a frog produces a specific negative chronotropic effect without decreasing its amplitude, while its application to the ventricle -- a specific negative inotropic effect without decelerating the heart contractions rate. The application of atropine to the atria and ventricles eliminates the specific negative chrono- and inotropic effects of acetylcholine. The various ganglion-blocking agents do not eliminate these effects. The existence of a new membrane mechanism of perception of the specific effects of acetylcholine and of their synchronous transmission to the venous-atrial node and the ventricular myocardium is proved to be found in the atria and ventricles.
将乙酰胆碱应用于青蛙离体心脏的心房会产生特定的负性变时作用，而不降低其振幅，而将其应用于心室则产生特定的负性变力作用，而不使心脏收缩速率减慢。将阿托品应用于心房和心室可消除乙酰胆碱的特定负性变时和变力作用。各种神经节阻断剂不会消除这些作用。已证实在心房和心室中存在一种新的膜机制，用于感知乙酰胆碱的特定作用并将其同步传递至静脉窦房结和心室心肌。
