Sokolova N A, Krasil'nikova V G, Ashmarin I P
Nauchnye Doki Vyss Shkoly Biol Nauki. 1990(10):80-5.
Opioid dermorphin induced a negative inotropic effect on the isolated perfused by Straube frog's heart, this effect was blocked by naloxone. On the background of dermorphin negative inotropic effect acetylcholine inhibited the ventricular contractile activity to the same degree as in the control experiments before dermorphin injection. But after the combined infusion of naloxone and dermorphin removed the opioid inotropic effect, the negative inotropic effect of acetylcholine became significantly weaker than in the control. It has been concluded that there are opiate receptors in the frog's ventricular myocardium, their activation leads to the negative inotropic effect. Dermorphin may act like atropine on the inotropic effects of acetylcholine, this action doesn't depend on the opiate receptors activation.
阿片类物质德尔吗啡对经斯特劳贝法灌注的离体青蛙心脏产生负性变力作用，这种作用可被纳洛酮阻断。在德尔吗啡负性变力作用的背景下，乙酰胆碱对心室收缩活动的抑制程度与注射德尔吗啡前的对照实验相同。但在联合输注纳洛酮和德尔吗啡消除阿片类物质的变力作用后，乙酰胆碱的负性变力作用比对照实验中明显减弱。由此得出结论，青蛙心室心肌中存在阿片受体，其激活会导致负性变力作用。德尔吗啡对乙酰胆碱变力作用的影响可能与阿托品类似，这种作用不依赖于阿片受体的激活。
