Devlin J W, Bellamy N, Bayliff C D
Victoria Hospital, London, Ontario.
Can J Hosp Pharm. 1992 Feb;45(1):21-7.
Allopurinol has been used in the management of hyperuricemic states for several years. Despite its efficacy for these indications, recent concerns have been raised regarding the unnecessary morbidity and mortality occasionally associated with its inappropriate use. In an effort to assess the utilization of allopurinol, a concurrent drug utilization review was undertaken. Fifty patients who were prescribed allopurinol were entered into the study and underwent health record review and patient interview, to determine appropriateness of therapy and the need for educational intervention. A number of inconsistencies with regard to established guidelines were identified. As well, 11 of 50 patients (22%) required intervention because of either lack of indication or excessive dose. Fifty-five percent of the educational interventions, performed by the pharmacist, were accepted as written. The current utilization of allopurinol at our facility differs substantially from guidelines developed for optimal utilization of allopurinol. Further, a pharmacy based intervention program can improve prescribing practices of allopurinol.
多年来，别嘌醇一直用于治疗高尿酸血症。尽管它对这些适应症有效，但最近人们对其不当使用偶尔导致的不必要发病和死亡表示担忧。为了评估别嘌醇的使用情况，同时进行了药物利用审查。五十名被开了别嘌醇的患者进入该研究，并接受健康记录审查和患者访谈，以确定治疗的适当性和教育干预的必要性。发现了一些与既定指南不一致的情况。此外，50名患者中有11名（22%）因缺乏适应症或剂量过大而需要干预。药剂师进行的教育干预中有55%被原样接受。我们机构目前别嘌醇的使用情况与为优化别嘌醇使用而制定的指南有很大不同。此外，基于药房的干预计划可以改善别嘌醇的处方习惯。
