McClintock A D, Egan A J, Woods D J, Pillans P I
Pharmacy Department, Dunedin Hospital.
N Z Med J. 1995 Aug 25;108(1006):346-7.
To evaluate the appropriateness of allopurinol dosage according to renal function in patients at Dunedin and Wakari hospitals.
A prospective survey of all patients receiving allopurinol therapy at Dunedin and Wakari hospitals during a four week period in January/February 1994 was performed. Data were collected from medication charts, patient notes and laboratory records. Dosage prescribed was compared with established guidelines.
Of 46 patients on allopurinol treatment 18 were prescribed at least 100 mg more than the recommended daily dose. Twenty-nine out of the 46 surveyed patients (median age 77 years) had mild to moderate renal impairment.
A significant proportion of patients were receiving excessive doses. Although information regarding the allopurinol hypersensitivity syndrome and individualised allopurinol dosage is available, it is evident that many practitioners remain unaware of the recommendations.
评估达尼丁医院和瓦卡里医院患者根据肾功能使用别嘌醇剂量的合理性。
对1994年1月/2月四周期间在达尼丁医院和瓦卡里医院接受别嘌醇治疗的所有患者进行前瞻性调查。数据从用药记录、患者病历和实验室记录中收集。将规定剂量与既定指南进行比较。
在46名接受别嘌醇治疗的患者中，18名患者的处方剂量比推荐日剂量至少多100毫克。46名接受调查的患者（中位年龄77岁）中有29名患有轻度至中度肾功能损害。
相当一部分患者接受了过量剂量。尽管有关于别嘌醇超敏综合征和个体化别嘌醇剂量的信息，但显然许多从业者仍然不知道这些建议。
