Plotkin M B, Foss M L, Goldin B, Ellis D G
Med Sci Sports. 1976 Winter;8(4):230-4.
It has been suggested that glucocorticoid drug therapy or usage may be a contributing factor in the occurrence of tendon ruptures among athletes. Our earlier findings (7) did not support this position but may have been dependent on the small quantity of drug injected. We subsequently tested selected biomechanical properties of healthy, non-traumatized tail tendons from sixty 90-day-old Sprague-Dawley rats previously injected weekly for six weeks with 0.1 ml saline (controls) or low (0.03 mg/0.1 ml), medium (0.30 mg/0.1 ml) or high doses (0.60 mg/0.1 ml) of betamethasone. Results indicate the biological effectiveness of the medium and high dose treatments through reductions in body and adrenal weights, but we found no statistically significant change in dry tendon weight, yield load or relative yield load, although there was a suggestive trend toward lessened dry tendon weights and greater relative yield loads. The hypothesis that repeated local injections of an anti-inflammatory steroid deleteriously effects mechanical properties of healthy, non-traumatized rat tendons is not supported by our data, even considering that some dosages were 10 to 20 times greater than recommended therapeutic quantities for humans.
有人提出，糖皮质激素药物治疗或使用可能是运动员肌腱断裂发生的一个促成因素。我们早期的研究结果（7）并不支持这一观点，但可能取决于注射的药物量较少。随后，我们测试了60只90日龄的Sprague-Dawley大鼠健康、未受创伤的尾腱的选定生物力学特性，这些大鼠此前每周注射一次，持续六周，分别注射0.1 ml生理盐水（对照组）或低剂量（0.03 mg/0.1 ml）、中剂量（0.30 mg/0.1 ml）或高剂量（0.60 mg/0.1 ml）的倍他米松。结果表明，中高剂量治疗通过降低体重和肾上腺重量具有生物学有效性，但我们发现干腱重量、屈服负荷或相对屈服负荷没有统计学上的显著变化，尽管有迹象表明干腱重量有减轻趋势，相对屈服负荷有增加趋势。我们的数据不支持反复局部注射抗炎类固醇会对健康、未受创伤的大鼠肌腱的力学性能产生有害影响这一假设，即使考虑到某些剂量比人类推荐治疗量高10至20倍。
