Sturrock R F, Butterworth A E, Houba V
Parasitology. 1976 Dec;73(3):239-52. doi: 10.1017/s003118200004693x.
The course of infection with a local strain of Schistosoma mansoni was investigated in Kenyan baboons (Papio anubis). A single exposure to 5000 cercariae per baboon (cpb) killed five 4-8 kg baboons; a sixth survived the full 30-week post-exposure period, with suppressed egg production after week 11. Lower doses were not lethal. A single exposure to 1000 cpb gave satisfactory adult worm recoveries, high and steady faecal egg excretion, and a high tissue egg recovery, predominantly from the large intestine. A similar but less consistent picture was obtained with a single exposure to 200 cpb. Baboons receiving 5 monthly exposures of 200 cpb (1000 cpb total) showed some evidence of the development of protective immunity. Three animals showed patterns resembling those for 200 and 1000 cpb. The other 3 had suppressed egg production (faecal and tissue) indicating, perhaps, some immunological process. They also had an abnormally high percentage of eggs in the liver.
对肯尼亚狒狒（埃及狒狒）感染当地曼氏血吸虫株的病程进行了研究。每只狒狒单次暴露于5000条尾蚴（每只狒狒的尾蚴数，cpb）导致5只4 - 8千克重的狒狒死亡；第六只在暴露后的整个30周期间存活下来，但在第11周后产卵量受到抑制。较低剂量不具有致死性。每只狒狒单次暴露于1000条尾蚴可获得令人满意的成虫回收率、高且稳定的粪便虫卵排泄量以及高组织虫卵回收率，主要来自大肠。每只狒狒单次暴露于200条尾蚴时得到了类似但不太一致的结果。接受5次每月200条尾蚴暴露（总计1000条尾蚴）的狒狒显示出一些保护性免疫发展的迹象。三只动物呈现出与200条和1000条尾蚴暴露时相似的模式。另外三只动物的虫卵产生（粪便和组织中的）受到抑制，这或许表明存在某种免疫过程。它们肝脏中的虫卵比例也异常高。
