Jaffe J J, Doremus H M, Dunsford H A, Meymarian E
Am J Trop Med Hyg. 1975 Mar;24(2):289-97. doi: 10.4269/ajtmh.1975.24.289.
Schistosomiasis japonica in capuchin msnkeys (Cebus apella) and schistosomiasis mansoni in baboons (Papio cyanocephalus and P. hamadryas) were completely arrested for 6 months in every infected primate receiving a single treatment with tubercidin (Tu), administered after prior absorption into 20% of their red cells. It is very likely that a single treatment with Tu sequestered in only 15% of the hosts' red cells would also be 100% effective for prolonged periods of time, but that with lower doses some relapses would be expected. Babbons with patent Schistosoma mansoni infections were rechallenged with S. mansoni cercariae 4 months after treatment with Tu. Although Tu eliminated almost all the sexually mature female worms from the primary infection but spared most of the males for continuing sojourn within their hosts, the baboons retained their full susceptibility to reinfection, as indicated by worm burdens and fecal egg excretion. However, the granulomatous reaction in the rechallenged Tu-treated baboons to new masses of eggs trapped in their livers appeared to be less intense than was seen in animals with primary infections.
卷尾猴（僧帽猴属）的日本血吸虫病以及狒狒（青头狒狒和阿拉伯狒狒）的曼氏血吸虫病，在每只接受结核菌素（Tu）单次治疗的感染灵长类动物中完全得到控制达6个月，结核菌素在事先被20%的红细胞吸收后给药。极有可能的是，仅在15%的宿主红细胞中隔离的单次Tu治疗在较长时间内也会100%有效，但剂量较低时预计会有一些复发情况。用Tu治疗4个月后，对患有曼氏血吸虫显性感染的狒狒再次用曼氏血吸虫尾蚴进行攻击。尽管Tu消除了初次感染中几乎所有性成熟的雌虫，但保留了大部分雄虫，使其继续寄生于宿主体内，但狒狒对再感染仍保持完全易感性，这从虫负荷和粪便虫卵排泄情况可以看出。然而，再次攻击的经Tu治疗的狒狒对肝脏中截留的新虫卵团块的肉芽肿反应似乎不如初次感染动物中那么强烈。
