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退热药的抗脂解活性研究。第二部分。水杨酸钠、氨基比林和非那西丁对去甲肾上腺素和氨茶碱体外刺激脂解作用的影响。

Studies on antilipolytic activity of antipyretics. Part II. Influence of sodium salicylate, aminophenazone, and acetophenidin on lipolysis stimulated by noradrenaline and aminophylline in vitro.

作者信息

Matuszek M

出版信息

Pol J Pharmacol Pharm. 1976;28(5):437-42.

PMID:1012973
Abstract

Lipolysis, expressed as muEq of FFA released from 1 g of epidydymal fat tissue per hour, was stimulated by noradrenaline (NA) and aminophyline. Sodium salicylate inhibited the lipolysis stimulated by NA, but not by aminophylline. Aminophenazone and acetophenidin inhibited the lipolysis stimulated either by NA or by aminophylline. The antipyretics inhibited stimulated lipolysis in a non-competitive manner. The results suggest an important role of the action of antipyretics on lipolysis in their hypothermizing action.

摘要

脂解作用以每小时从1克附睾脂肪组织释放的游离脂肪酸（FFA）的微当量表示，去甲肾上腺素（NA）和氨茶碱可刺激脂解作用。水杨酸钠可抑制NA刺激的脂解作用，但不抑制氨茶碱刺激的脂解作用。氨基比林和非那西汀可抑制NA或氨茶碱刺激的脂解作用。这些解热药以非竞争性方式抑制刺激的脂解作用。结果表明，解热药对脂解作用的影响在其降温作用中起重要作用。

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