脑内单胺能系统损伤对大鼠可乐定降压作用的影响。
Effects of lesions of monoaminergic system in the brain on the hypotensive effects of clonidine in rats.
作者信息
Szreniawski Z, Kostowski W, Widy-Tyszkiewicz E
出版信息
Pol J Pharmacol Pharm. 1976 Nov-Dec;28(6):605-8.
PMID:1012984
Abstract
Bilateral lesions of the locus coeruleus markedly reduced hypotensive effects of clonidine in rats. Lesions shifted laterally did not evoke any significant change of the hypotensive effects of clonidine or bradycardia induced by it. Lesions of the ventral and dorsal noradrenergic tract at the midbrain level and lesions of the midbrain raphe area failed to change hypotensive response to clonidine.
摘要
蓝斑双侧损伤显著降低了可乐定对大鼠的降压作用。向外侧移位的损伤并未引起可乐定降压作用或其诱导的心动过缓的任何显著变化。中脑水平的腹侧和背侧去甲肾上腺素能束损伤以及中脑缝际区损伤未能改变对可乐定的降压反应。
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