蓝斑及腹侧去甲肾上腺素能束损伤对大鼠可乐定抗伤害感受作用的影响。
Effects of lesions of the Locus coeruleus and the ventral noradrenergic bundle on the antinociceptive action of clonidine in rats.
作者信息
Kostowski W, Jerlicz M
出版信息
Pol J Pharmacol Pharm. 1978 Sep-Oct;30(5):647-51.
PMID:751006
Abstract
Effects of electrolytic lesions of noradrenergic brain systems on clonidine-induced analgesia were tested in rats by tail-compression method. Bilateral lesions of the locus coereleus decreased clonidine analgesia whilst lesions involving the ventral noradrenergic bundle produced no significant effect. These data demonstrate that antinociceptive effect of clonidine is related to action upon the noradrenergic system of the locus coeruleus.
摘要
通过尾部压迫法在大鼠中测试了去甲肾上腺素能脑系统的电解损伤对可乐定诱导镇痛的影响。蓝斑的双侧损伤降低了可乐定的镇痛作用，而涉及腹侧去甲肾上腺素能束的损伤则没有显著影响。这些数据表明，可乐定的抗伤害感受作用与对蓝斑去甲肾上腺素能系统的作用有关。
相似文献
1
Effects of lesions of the Locus coeruleus and the ventral noradrenergic bundle on the antinociceptive action of clonidine in rats.蓝斑及腹侧去甲肾上腺素能束损伤对大鼠可乐定抗伤害感受作用的影响。
Pol J Pharmacol Pharm. 1978 Sep-Oct;30(5):647-51.
2
Evidence for the locus coeruleus involvement in desipramine action in animal models of depression.在抑郁症动物模型中，蓝斑核参与地昔帕明作用的证据。
Pol J Pharmacol Pharm. 1985 Nov-Dec;37(6):855-64.
3
Effect of lesions of the brain noradrenergic systems on amphetamine-induced hyperthermia and locomotor stimulation.脑去甲肾上腺素能系统损伤对苯丙胺诱导的体温过高和运动兴奋的影响。
Acta Physiol Pol. 1982 Jul-Aug;33(4):383-7.
4
5
Reduced analgesic effects of morphine after bilateral lesions of the locus coeruleus in rats.大鼠蓝斑双侧损伤后吗啡镇痛作用减弱。
Pol J Pharmacol Pharm. 1978 Jan-Feb;30(1):49-53.
6
Total neurochemical lesion of noradrenergic neurons of the locus ceruleus does not alter either naloxone-precipitated or spontaneous opiate withdrawal nor does it influence ability of clonidine to reverse opiate withdrawal.蓝斑去甲肾上腺素能神经元的完全神经化学损伤既不会改变纳洛酮诱发的或自发的阿片戒断反应，也不会影响可乐定逆转阿片戒断反应的能力。
J Pharmacol Exp Ther. 1999 Aug;290(2):881-92.
7
Effects of lesion of the locus coeruleus and clonidine treatment on ethanol withdrawal syndrome in rats.蓝斑损毁及可乐定治疗对大鼠乙醇戒断综合征的影响。
Pol J Pharmacol Pharm. 1980 Sep-Oct;32(5):617-23.
8
Possible relationship of the locus coeruleus--hippocampal noradrenergic neurons to depression and mode of action of antidepressant drugs.蓝斑-海马去甲肾上腺素能神经元与抑郁症的可能关系及抗抑郁药物的作用模式。
Pol J Pharmacol Pharm. 1985 Nov-Dec;37(6):727-43.
9
Effects of lesions of monoaminergic system in the brain on the hypotensive effects of clonidine in rats.脑内单胺能系统损伤对大鼠可乐定降压作用的影响。
Pol J Pharmacol Pharm. 1976 Nov-Dec;28(6):605-8.
10
Intrinsic neural circuits between dorsal midbrain neurons that control fear-induced responses and seizure activity and nuclei of the pain inhibitory system elaborating postictal antinociceptive processes: a functional neuroanatomical and neuropharmacological study.控制恐惧诱发反应和癫痫活动的中脑背侧神经元与阐述发作后抗伤害感受过程的疼痛抑制系统核团之间的内在神经回路：一项功能神经解剖学和神经药理学研究。
Exp Neurol. 2005 Feb;191(2):225-42. doi: 10.1016/j.expneurol.2004.10.009.
Zotero 插件