地高辛进入脑脊液的情况。
Penetration of digoxin into cerebrospinal fluid.
作者信息
Schott G D, Holt D W, Hayler A M
出版信息
Postgrad Med J. 1976 Nov;52(613):700-2. doi: 10.1136/pgmj.52.613.700.
Abstract
The concentration of digoxin in the cerebrospinal fluid (CSF) of ten patients receiving conventional oral doses of this cardiac glycoside has been measured by a radioimmunoassay technique. Digoxin was undetected in eight patients and barely detectable in two, suggesting the presence of a significant blood-CSF barrier for digoxin. The implication of these findings is discussed.
摘要
采用放射免疫分析技术测定了10例接受常规口服剂量这种强心苷的患者脑脊液（CSF）中地高辛的浓度。8例患者脑脊液中未检测到地高辛，2例患者仅能勉强检测到，提示地高辛存在显著的血脑屏障。讨论了这些发现的意义。
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