[Controlled hypotension by sodium nitroprusside during neuroleptanalgesia, halothane-and enflurane anaesthesia at neurosurgical and maxillary-face-surgical operations (author's transl)].

A new sodium-nitroprusside-preparation (Nipruss) was tested in 40 patients for a controlled hypotension in neurosurgical as well as maxillary- and face-surgical operations. Differences between the phases of hypotension by Nipruss were pointed out for NLA, halothane- and enflurane-narcosis. An initial hypotension of -48 per cent, caused by Nipruss, was accompanied by an increase of the cardiac frequency of +33 per cent. This was dependent on the different methods of anaesthesia. The doses necessary for an average permanent hypotension of -36 per cent varied between 1.3 and 22.3mug/kg/min. The results proved, that Nipruss guarantees a diminished blood field even be used without head-up-position and at moderate hypotension. In combination with halothane and enflurane, hypotension could be regulated easier than with NLA. However, this resulted often in a higher frequencyload of the heart, so that frequently beta-adrenergic blocking drugs had to be administered. The operation conditions were improved, incidents did not occur. The new preparation Nipruss has organizational and hygienic advantages.