Landauer B
Anaesthesist. 1976 Jun;25(6):266-73.
Sodium notroprusside (Nipruss), in comparison with halothane and trimetaphan a very suitable hypotensive drug, was examined for blood pressure lowering efficency and possible side effects. For this purpose 7 patients (group 1) underwent "classical" hypotension during neurosurgical procedures. In 5 cases (group 2) nitroprusside infusion was needed for therapy of hypertensive crisis during vascular surgery. In all patients the hypotensive action was prompt and sufficient. Low blood pressure was accompanied by a 22.5% rise of heart rate and a 66% fall of central venous pressure. The development of mild metabolic acidosis seemed to be without clinical importance. The doses employed ranged from 3 to 13 (grpup 1) and from 1.5 to 3.1 gamma/kg/min (group 2). Sodium nitroprusside proved a very useful hypotensive drug, fitting well with the needs of modern anaesthesia.
与氟烷和阿方那特相比，硝普钠（Nipruss）是一种非常合适的降压药物，对其降压效果和可能的副作用进行了研究。为此，7名患者（第1组）在神经外科手术期间接受了“经典”低血压治疗。在5例患者（第2组）中，血管手术期间治疗高血压危象需要输注硝普钠。在所有患者中，降压作用迅速且充分。低血压伴随着心率上升22.5%和中心静脉压下降66%。轻度代谢性酸中毒的发生似乎没有临床意义。使用的剂量范围为3至13（第1组）和1.5至3.1微克/千克/分钟（第2组）。硝普钠被证明是一种非常有用的降压药物，非常符合现代麻醉的需求。
