Lipshitz J, Baillie P, Davey D A
S Afr Med J. 1976 Nov 17;50(49):1969-72.
A study was undertaken to compare the uterine beta2-adrenoreceptor selectivity of fenoterol, hexoprenaline, ritodrine and salbutamol. The drugs in doses having an equivalent effect on uterine activity, were randomly administered as an intravenous bolus to 10 patients who had been induced at term. The cardiovascular and uterine effects of the drugs were recorded. The rise in maternal pulse rate was significantly less (P less than 0,001) after the administration of hexoprenaline when it was compared with fenoterol, ritodrine, and salbutamol. Hexoprenaline proved to be the most chronotropically beta2-selective drug, having the least effect on the beta1-adrenoreceptors of the heart, for an equivalent effect on the uterus. Blood pressure changes were less significantly different between the drugs. The clinical use in obstetrics of a highly beta2-selective sympathomimetic drug is discussed.
进行了一项研究以比较非诺特罗、海索那林、利托君和沙丁胺醇对子宫β2-肾上腺素能受体的选择性。将对子宫活动有等效作用剂量的药物作为静脉推注随机给予10名足月引产的患者。记录药物的心血管和子宫效应。与非诺特罗、利托君和沙丁胺醇相比，海索那林给药后母体脉搏率的升高显著更低（P小于0.001）。对于子宫等效效应，海索那林被证明是最具变时性β2选择性的药物，对心脏β1-肾上腺素能受体的影响最小。药物之间血压变化的差异不太显著。讨论了高β2选择性拟交感神经药物在产科的临床应用。
