Baumgarten K, Lingard W, Horvat A, Chalkitis J, Cerwenka R, Hellmich C
Geburtshilfe Frauenheilkd. 1982 Feb;42(2):103-14. doi: 10.1055/s-2008-1036646.
Puerperal uteri were stimulated by oxytocin, the uterine motility was recorded by transcervical catheter techniques, maternal pulse and blood-pressure were recorded continuously or intermittently. Oral tocolytics as Gynipral (Hexoprenaline), Partusisten (Fenoterol), Spiropent (Clenbuterol) and Prepar (Ritodrine) were administered orally in single or double dose. The inhibitory effect of these drugs were recorded, evaluated from the records and calculated statistically concerning their significant differences. It could be demonstrated that only Hexoprenaline in a three time higher dose than used usually and Partusisten in a dose of 10 and 20 mg were able to reduce uterine motility for more than 50%. All other substances definitely had an inhibitory effect on the puerperal uterus, but inhibition was not stronger than 30%. Cardiovascular side-effects were discussed. The question, if oral given betamimetics are effective in the treatment of threatening premature labour could not be answered definitively, but there are doubts according this study concerning the dose and the repetition of it for this purpose.
用催产素刺激产后子宫，通过经宫颈导管技术记录子宫活动，连续或间断记录产妇脉搏和血压。口服宫缩抑制剂如Gynipral（海索那林）、Partusisten（酚妥拉明）、Spiropent（克仑特罗）和Prepar（利托君），单剂量或双剂量口服。记录这些药物的抑制作用，根据记录进行评估，并对其显著差异进行统计学计算。结果表明，只有剂量比通常使用的高三倍的海索那林以及剂量为10毫克和20毫克的酚妥拉明能够使子宫活动减少超过50%。所有其他物质对产后子宫肯定有抑制作用，但抑制作用不超过30%。讨论了心血管副作用。口服β-拟交感神经药在治疗先兆早产方面是否有效这一问题无法明确回答，但根据这项研究，对于为此目的使用的剂量及其重复使用存在疑问。
