肺癌患者淋巴细胞中的腺苷脱氨酶和嘌呤核苷磷酸化酶活性

Adenosine deaminase and purine nucleoside phosphorylase activities in lymphocytes from patients with lung cancer.

作者信息

Ogawa K, Tominaga K, Taoka S, Yata K, Tsubura E

出版信息

Gan. 1978 Aug;69(4):471-5.

Abstract

The activity of adenosine deaminase (EC 3.5.4.4.) was significantly lower in lymphocytes from patients with lung cancer than in those from healthy subjects, whereas the activity of purine nucleoside phosphorylase (EC 2.4.2.1.) was significantly higher in lymphocytes from the patients than in those from normal controls. When the one activity was plotted against the other, the plots for patients with lung cancer were all outside the frame formed by the lower and higher limits of the standard deviation of the mean of normal activities of the two enzymes. The ratio of adenosine deaminase activity to purine nucleoside phosphorylase activity was lower in patients with lung cancer than in controls. The possible effect of this ratio on the function of lymphocytes was briefly discussed. These enzyme activities were suggested to be useful measures of the immune responsiveness of patients with lung cancer.

摘要

肺癌患者淋巴细胞中腺苷脱氨酶（EC 3.5.4.4.）的活性显著低于健康受试者的淋巴细胞，而嘌呤核苷磷酸化酶（EC 2.4.2.1.）的活性在肺癌患者淋巴细胞中显著高于正常对照者。当将一种酶的活性与另一种酶的活性作图时，肺癌患者的图均位于由两种酶正常活性均值标准差的下限和上限所构成的范围之外。肺癌患者腺苷脱氨酶活性与嘌呤核苷磷酸化酶活性的比值低于对照组。简要讨论了该比值对淋巴细胞功能可能产生的影响。这些酶活性被认为是衡量肺癌患者免疫反应性的有用指标。

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