Kojima O, Majima T, Uehara Y, Yamane T, Fujita Y, Takahashi T, Majima S
Jpn J Surg. 1985 Mar;15(2):130-3. doi: 10.1007/BF02469742.
The present study was undertaken to determine the adenosine deaminase (ADA) activity of peripheral lymphocytes in patients with gastric cancer, with respect to the cancer progression, the effect of surgery and/or immunotherapy. The gastric cancer patients showed lower lymphocyte ADA activity than did the normal control. The lymphocyte ADA activity did not decrease with the cancer progression. There was a significant correlation between lymphocyte ADA activity and blastogenesis of lymphocyte by phytohemaglutinin or concanavalin A. Six months following gastrectomy, the lymphocyte ADA activity was increased, as compared with the preoperative value. The ADA activity of patients on post-operative OK-432 showed a greater increase, as compared to that of patients not given this treatment. In conclusion, decreased lymphocyte ADA activity in gastric cancer patients might be due to either the cancer bearing status or to the immunological suppression.
本研究旨在确定胃癌患者外周淋巴细胞的腺苷脱氨酶（ADA）活性，以及其与癌症进展、手术和/或免疫治疗效果之间的关系。胃癌患者的淋巴细胞ADA活性低于正常对照组。淋巴细胞ADA活性并未随癌症进展而降低。淋巴细胞ADA活性与植物血凝素或刀豆球蛋白A诱导的淋巴细胞增殖之间存在显著相关性。胃切除术后六个月，淋巴细胞ADA活性较术前值有所增加。与未接受此治疗的患者相比，接受术后OK-432治疗的患者ADA活性增加更为明显。总之，胃癌患者淋巴细胞ADA活性降低可能是由于荷癌状态或免疫抑制所致。
