Hedstrand H, Vessby B
Ups J Med Sci. 1976;81(3):159-66. doi: 10.3109/03009737609179042.
Serum lipoprotein (LP) concentrations were determined and LP patterns were classified in 261 middle-aged men, recruited from a health examination survey, with serum lipid values above the 80th percentile of the same population. Individuals with hyperlipoproteinaemia (HLP) and normolipidaemic controls were characterized also regarding family history of cardiovascular disease, socio-economic factors and clinical and laboratory variables. Subjects with HLP type IV-V and IIB were overweight and showed hyperuricaemia and hyperinsulinaemia compared with normolipidaemic controls and subjects with HLP type IIA. The latter showed elevated erythrocyte sedimentation rate. In spite of being overweight, subjects with HLP type III showed normal fasting values of insulin and uric acid in serum and normal early insulin response to intravenous glucose. The glucose tolerance did not differ significantly between the groups. Men with HLP types IV-V had predominantly sedentary occupations, in contrast to those with type IIA. There were significantly more smokers in the groups with HLP type IIB and IV-V than in the control group. Thus, individuals with different types of HLP tend to show different metabolic profiles but also different socioeconomic and clinical patterns, suggesting that exogenous factors are of importance in the expression of the LP abnormalities.
对从健康检查调查中招募的261名中年男性进行血清脂蛋白（LP）浓度测定并对LP模式进行分类，这些男性的血脂值高于同人群的第80百分位数。还根据心血管疾病家族史、社会经济因素以及临床和实验室变量对高脂血症（HLP）患者和血脂正常的对照组进行了特征描述。与血脂正常的对照组和IIA型HLP患者相比，IV-V型和IIB型HLP患者超重，且出现高尿酸血症和高胰岛素血症。后者红细胞沉降率升高。尽管III型HLP患者超重，但血清胰岛素和尿酸的空腹值正常，对静脉注射葡萄糖的早期胰岛素反应也正常。各组之间的葡萄糖耐量无显著差异。与IIA型HLP患者相比，IV-V型HLP患者主要从事久坐不动的职业。IIB型和IV-V型HLP组中的吸烟者明显多于对照组。因此，不同类型HLP的个体往往表现出不同的代谢特征，以及不同的社会经济和临床模式，这表明外部因素在LP异常的表现中很重要。
