Paskhina T S, Nartikova V F, Dotsenko V L, Maslova T M, Morozova N A
Vopr Med Khim. 1976 Sep-Oct;22(5):696-707.
State of kinin system was studied in blood serum of patients with burns of II, III, IIIb and IV degrees during shock and early toxemia. Content or activity of main components of kinin system (kininogen, kallikreinogen, kallikrein, kininase I (carboxypeptidase N)) were repeatedly estimated at 4-6 hrs intervals; BAEE-esterase and antitryptic activities were also studied within 48-72 hrs after the trauma. At the same period plasminogen and plasmin were estimated in 8 patients. The activation of kinin system in burn shock was demonstrated: content of kininogen was decreased on 30-50% (independently on alteration of total protein in blood serum), the kininase activity was decreased, appearance of free kallikrein was observed and content of kallikreinogen was distinctly lowered already within 10-24 hrs after the trauma. Within 24 hrs after the burn the total decrease of kininogen in circulation accounted for 50-70% of the theoretical content. Fibrinolytic system was also activated during the burn shock. Increase in the antitryptic activity within 30-40 hrs after the trauma, which was previously established, is corroborated; the effect correlated with development of burn intoxication. The data obtained suggest that massive production of free kinins occur apparently within 24-48 hrs after burn.
对Ⅱ度、Ⅲ度、Ⅲb度和Ⅳ度烧伤患者在休克期和早期毒血症期血清中的激肽系统状态进行了研究。每隔4 - 6小时反复测定激肽系统主要成分（激肽原、激肽释放酶原、激肽释放酶、激肽酶Ⅰ（羧肽酶N））的含量或活性；在创伤后48 - 72小时内还研究了BAEE - 酯酶和抗胰蛋白酶活性。同期对8例患者的纤溶酶原和纤溶酶进行了测定。结果表明烧伤休克时激肽系统被激活：激肽原含量降低30 - 50%（与血清总蛋白的变化无关），激肽酶活性降低，观察到游离激肽释放酶的出现，且创伤后10 - 24小时内激肽释放酶原含量明显降低。烧伤后24小时内循环中激肽原的总降低量占理论含量的50 - 70%。烧伤休克期间纤溶系统也被激活。此前已证实创伤后30 - 40小时抗胰蛋白酶活性增加，本研究结果与之相符；该效应与烧伤中毒的发展相关。所获数据表明，烧伤后24 - 48小时内明显发生了大量游离激肽的产生。
