Emanuel' N M, Konovalova N P, D'iachkovskaia R F, Rozenberg A N
Vopr Onkol. 1976;22(10):72-7.
Toxic cumulative and antitumor properties of bifunctional N-nitroso-alkylureas as compared with their monofunctional analogues were stuied. Newly produced compounds render a considerable antitumor effect on a number of experimental tumors. A conclusion may be drawn that despite changes in the chemical structure an active metabolic fragment both of mono- and bifunctional compounds is the same, as also evidenced by the cumulation index. However, inspite of a rather high antitumor activity of bifunctional compounds their chemotherapeutic indices are very low.
研究了双功能N-亚硝基烷基脲与其单功能类似物相比的毒性累积和抗肿瘤特性。新合成的化合物对多种实验性肿瘤具有显著的抗肿瘤作用。可以得出结论，尽管化学结构发生了变化，但单功能和双功能化合物的活性代谢片段是相同的，累积指数也证明了这一点。然而，尽管双功能化合物具有相当高的抗肿瘤活性，但其化疗指数却非常低。
