Sharashidze L K, Turkiia N G, Lagidze D R, Adamiia I K, Asatiani V V
Eksp Onkol. 1989;11(2):62-5.
The antitumour activity of 10 analogs of nitroso alkyl urea was studied on 6 tumour strains. It was shown that antitumour effect depends upon the gentle structural changes of substances (changes of side chain, the position of aromatic nucleus in it, as well as the nature, quantity and position of substitutes in the nucleus). 7 compounds out of 10 analogs of nitroso alkyl urea have manifested antitumour activity.
研究了10种亚硝基烷基脲类似物对6种肿瘤菌株的抗肿瘤活性。结果表明，抗肿瘤效果取决于物质的细微结构变化（侧链变化、芳核在侧链中的位置，以及核中取代基的性质、数量和位置）。10种亚硝基烷基脲类似物中有7种表现出抗肿瘤活性。
