Horák D, Svec F, Adamyan A A, Titova M I, Dan V N, Trostenyuk N V, Voronkova O S, Gumargalieva K Z
Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Prague.
J Appl Biomater. 1993 Fall;4(3):253-9. doi: 10.1002/jab.770040307.
The application of superselective endovascular occlusion in vascular radiology has broadened the scope of possible radical surgery of giant angiodysplasias by reducing considerably the risk of severe haemorrhage during the surgery. Occlusion was performed on 229 patients using spherical and cylindrical particles of porous poly(2-hydroxyethyl methacrylate). The treatment of a patient suffering from angiodysplasia of the pelvis is described as an example. The first day following endovascular occlusion a hypercoagulation reaction developed, with a decrease of both the level of fibrinolysis and of anticoagulant factors. This was mainly due to a decrease of the level of antithrombin III and activation of the factor XIII indicating a strong tendency of intravascular thrombosis. During the third day, the hypercoagulation reaction increased. However, on the fifteenth day, parameters of the haemostasis system were close to normal values. Only the activity of the factor XIII remained high suggesting the stabilization and the organization of fibrin clot in the embolized blood vessel territory.
超选择性血管内闭塞术在血管放射学中的应用，通过大幅降低手术期间严重出血的风险，拓宽了巨大血管发育异常根治性手术的可能性范围。使用多孔聚（甲基丙烯酸2 - 羟乙酯）的球形和圆柱形颗粒对229例患者进行了闭塞术。以一名患有骨盆血管发育异常的患者的治疗为例进行描述。血管内闭塞术后第一天出现高凝反应，同时纤溶水平和抗凝因子均下降。这主要是由于抗凝血酶III水平降低以及因子XIII激活，表明有强烈的血管内血栓形成倾向。在第三天，高凝反应加剧。然而，在第十五天，止血系统参数接近正常水平。只有因子XIII的活性仍然较高，表明栓塞血管区域内纤维蛋白凝块的稳定和机化。
