Hardaway R M, Harke H, Williams C H
Texas Tech University School of Medicine, El Paso.
Adv Ther. 1994 Mar-Apr;11(2):43-51.
Nineteen patients suffering from adult respiratory distress syndrome (ARDS) secondary to trauma or sepsis, or both, failed to respond to treatment with mechanical ventilation with oxygen and positive end-expiratory pressure. On the premise that ARDS may be caused by the microclots of disseminated intravascular coagulation obstructing the pulmonary microcirculation, the patients were treated with either streptokinase or urokinase. Eighteen patients responded with significant improvement in PaO 2 value. No bleeding occurred and clotting parameters remained normal.
19名因创伤或脓毒症继发成人呼吸窘迫综合征（ARDS），或两者皆有的患者，对氧气和呼气末正压通气治疗无反应。基于ARDS可能由弥散性血管内凝血的微血栓阻塞肺微循环引起这一前提，这些患者接受了链激酶或尿激酶治疗。18名患者的动脉血氧分压（PaO₂）值显著改善。未发生出血，凝血参数保持正常。
