Hayes M J, Lauren M D
Columbia Laboratories, Inc., Buffalo, New York 14214.
J Appl Biomater. 1994;5(3):215-20. doi: 10.1002/jab.770050306.
Chemical stress relaxation methods are employed to study chemical and mechanical factors influencing the degradation of uncoated polyglycolic (PG) sutures. Specially constructed instrumentation is used to study the kinetics of the load bearing capability of PG (Dexon¿) 3-0 sutures in hydrolytic solution. The effects of pH, temperature, strain rate, and initial load on the rate of chemical stress relaxation are presented. Data show how mechanical factors such as the rate of loading (related to the speed of knot tying), as well as the final tension, are related to the rate of structural degradation. Maximum stability is observed at approximately 40 degrees C, with slower degradation both above and below this point. Results show that the slower and tighter the suture is pulled, the greater its ability to sustain tensile loads during hydrolysis.
采用化学应力松弛方法研究影响未涂层聚乙醇酸（PG）缝线降解的化学和机械因素。使用专门构建的仪器研究PG（Dexon®）3-0缝线在水解溶液中的承载能力动力学。给出了pH值、温度、应变率和初始负荷对化学应力松弛速率的影响。数据表明诸如加载速率（与打结速度有关）以及最终张力等机械因素如何与结构降解速率相关。在约40摄氏度时观察到最大稳定性，高于和低于此温度时降解均较慢。结果表明，缝线牵拉得越慢且越紧，其在水解过程中承受拉伸负荷的能力就越强。
