Kirby T J, Mehta A
Department of Cardiothoracic Surgery, Cleveland Clinic Foundation, Ohio 44195.
Appl Cardiopulm Pathophysiol. 1992;4(4):263-71.
Since the first long term successful single lung transplant in 1983, followed by a successful double lung transplant in 1986, lung transplantation has become established world-wide as an accepted option in the treatment of end-stage respiratory disease of various etiologies. Both procedures carry acceptable morbidity and mortality rates with the actuarial 5 year survivor rate of 80%. Single or double lung transplantation offers many advantages over heart-lung transplantation and is gradually supplanting the latter in most centers with certain exceptions. Differentiating injection from rejection continues to be a major problem but with added experience and new diagnostic tools this obstacle will be overcome.
自1983年首次长期成功进行单肺移植，随后于1986年成功进行双肺移植以来，肺移植已在全球范围内确立为治疗各种病因所致终末期呼吸系统疾病的一种可接受的选择。这两种手术的发病率和死亡率均可接受，精算5年生存率为80%。单肺或双肺移植相比心肺移植具有许多优势，并且在大多数中心正逐渐取代后者，但有某些例外情况。区分感染与排斥反应仍然是一个主要问题，但随着经验的增加和新诊断工具的出现，这一障碍将被克服。
