Yokoyama I, Uchida K, Tominaga Y, Asano H, Orihara A, Takagi H
Nagoya University School of Medicine, Department of Surgery II, Japan.
Clin Transplant. 1993 Jun;7(3):258-62.
One-hundred-and-twenty patients underwent first cadaveric kidney transplantation from the non-heart beating donors. All of the organs were procured with the use of double balloon catheter for in situ cooling. The mean warm ischemic time and cold ischemic time were 10.7 +/- 17.0 minutes and 18.9 +/- 11.4 hours, respectively. One- and 5-year graft survival rates were 85.0 and 72.7%, respectively. Among 120 recipients, 30 (25%) grafts functioned immediately (immediate function), 82 (68.3%) grafts functioned after varying length of oliguric periods (delayed function) and 8 (6.7%) grafts never functioned (non-function). The mean age of the donors in the group of immediate function (31.5 +/- 16.1 yr) was significantly lower than those of other two groups. The mean warm ischemic time in the group of immediate function (6.0 +/- 11.2 min) was significantly shorter than that of delayed function. However, there was no significant difference in donor hypotensive episode, types of preservation fluid and cold ischemic time between the groups. The conclusion is that the ultimate result of cadaveric kidney transplant from the non-heart beating donors with the use of double lumen catheter is acceptable despite a relatively high incidence of delayed graft function.
120例患者接受了首例来自非心脏跳动供体的尸体肾移植。所有器官均使用双球囊导管进行原位冷却获取。平均热缺血时间和冷缺血时间分别为10.7±17.0分钟和18.9±11.4小时。1年和5年移植肾存活率分别为85.0%和72.7%。在120例受者中,30例(25%)移植肾立即发挥功能(即时功能),82例(68.3%)移植肾在不同时长的少尿期后发挥功能(延迟功能),8例(6.7%)移植肾从未发挥功能(无功能)。即时功能组供者的平均年龄(31.5±16.1岁)显著低于其他两组。即时功能组的平均热缺血时间(6.0±11.2分钟)显著短于延迟功能组。然而,各组之间在供者低血压发作、保存液类型和冷缺血时间方面无显著差异。结论是,尽管移植肾延迟功能发生率相对较高,但使用双腔导管进行非心脏跳动供体尸体肾移植的最终结果是可以接受的。