Tseng Y C, Hyon S H, Ikada Y, Shimizu Y, Tamura K, Hitomi S
Research Center for Medical Polymers and Biomaterials, Kyoto University, Japan.
J Appl Biomater. 1990 Summer;1(2):111-9. doi: 10.1002/jab.770010203.
To evaluate 2-cyanoacrylates as surgical adhesives, the bond strength in vivo as well as the tissue reaction was investigated using methyl-, ethyl-, isobutyl-, and ethoxyethyl-2-cyanoacrylate. In addition, their set time and spreading on blood were studied. When the 2-cyanoacrylates were applied to an incised site of rabbit skin, they could maintain the skin closure without suturing during the first week and the bond strength increased during the second week. Significant inflammatory response was observed around the subcutaneous tissue glued with methyl- and ethoxyethyl-2-cyanoacrylate and persisted for approximately one week. All the 2-cyanoacrylate polymers were absorbed and the tissues treated were healed two weeks after the operation. There was a mild inflammatory reaction in the tissue treated with ethyl- and isobutyl-2-cyanoacrylate, and their polymers still remained at the wound site at the second week postoperatively. The disappearance rate of the 2-cyanoacrylate polymers was roughly in proportion to the inflammatory tissue response. Ethoxyethyl-2-cyanoacrylate spread more broadly on tissues than the other 2-cyanoacrylates, while its set time was shorter than that of methyl- and ethyl-2-cyanoacrylates.
为评估2-氰基丙烯酸酯类作为手术黏合剂的性能，使用甲基、乙基、异丁基和乙氧基乙基-2-氰基丙烯酸酯对其体内黏合强度以及组织反应进行了研究。此外，还研究了它们的固化时间和在血液中的铺展情况。当将2-氰基丙烯酸酯类应用于兔皮肤切口部位时，在第一周内它们可不缝合而维持皮肤闭合，且在第二周黏合强度增加。在用甲基和乙氧基乙基-2-氰基丙烯酸酯黏合的皮下组织周围观察到明显的炎症反应，且持续约一周。所有2-氰基丙烯酸酯聚合物均被吸收，手术两周后处理的组织愈合。在用乙基和异丁基-2-氰基丙烯酸酯处理的组织中有轻度炎症反应，且在术后第二周其聚合物仍留在伤口部位。2-氰基丙烯酸酯聚合物的消失速率大致与炎症组织反应成比例。乙氧基乙基-2-氰基丙烯酸酯在组织上的铺展比其他2-氰基丙烯酸酯更广泛，而其固化时间比甲基和乙基-2-氰基丙烯酸酯短。
