Bhat S, Askew M J, Njus G, Smith D J
Department of Biomedical Engineering, University of Akron, OH 44325.
J Appl Biomater. 1992 Fall;3(3):207-10. doi: 10.1002/jab.770030307.
Higher chained alkyl cyanoacrylates have potential to function efficiently as space filling, hydrophobic, viscoelastic, biocompatible, and rapidly polymerizing bone adhesives. Hence they may be useful in applications where a void has to be filled, such as replacement of the intervertebral disc. To assess their applicability as space filling material in such an application, three alkyl cyanoacrylates; methoxyethyl cyanoacrylate, isobutyl cyanoacrylate, and isoamyl cyanoacrylate have been evaluated in this study. The bonding strength of these cyanoacrylates to bone in a space filling situation have been measured. The results indicate the bond strength of isoamyl cyanoacrylate (0.13 MPa) to be significantly (p less than 0.05) lower compared with methoxyethyl cyanoacrylate (0.33 MPa) and isobutyl cyanoacrylate (0.37 MPa). There was no significant difference in the bond strengths of isobutyl cyanoacrylate and methoxyethyl cyanoacrylate.
高级链状烷基氰基丙烯酸酯有潜力高效地发挥作用，作为填充空间、疏水、粘弹性、生物相容性且快速聚合的骨粘合剂。因此，它们可能在需要填充空隙的应用中有用，比如椎间盘置换。为了评估它们在这种应用中作为填充材料的适用性，本研究对三种烷基氰基丙烯酸酯进行了评估，即甲氧基乙基氰基丙烯酸酯、异丁基氰基丙烯酸酯和异戊基氰基丙烯酸酯。已测量了这些氰基丙烯酸酯在填充空间情况下与骨的结合强度。结果表明，与甲氧基乙基氰基丙烯酸酯（0.33兆帕）和异丁基氰基丙烯酸酯（0.37兆帕）相比，异戊基氰基丙烯酸酯的结合强度（0.13兆帕）显著更低（p小于0.05）。异丁基氰基丙烯酸酯和甲氧基乙基氰基丙烯酸酯的结合强度没有显著差异。
