Lloyd T R, Markowitz M A
Steele Memorial Children's Research Center, The University of Arizona, Tucson.
J Invasive Cardiol. 1992 May;4(4):167-72.
Implantation of 3.5 mm Gianturco-Roubin coronary artery stents into the ductus arteriosus was evaluated as an alternative to surgical systemic to pulmonary arterial shunts in 3 weanling piglets. Thrombosis of the ductus occurred in all 3 animals (95% confidence limits 29-100%) within 1 hour, despite pretreatment with heparin. In each case, thrombus filled the ductus arteriosus but did not extend to any extraductal portion of the stents. Rapid, heparin-resistant thrombus formation precludes use of this stent procedure as an alternative to surgical shunts.
在3只断奶仔猪中,评估了将3.5毫米的Gianturco-Roubin冠状动脉支架植入动脉导管作为手术性体肺分流术替代方案的可行性。尽管术前使用了肝素,但所有3只动物(95%置信区间29-100%)的动脉导管均在1小时内发生血栓形成。在每种情况下,血栓充满动脉导管,但未延伸至支架的任何导管外部分。快速形成的肝素抵抗性血栓使这种支架手术无法作为手术分流的替代方案。