Bloom B S
Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia.
Pharmacoeconomics. 1992 Mar;1(3):175-81. doi: 10.2165/00019053-199201030-00004.
All healthcare services, however beneficial, carry inherent risks in addition to the costs of care, which may involve expenditures on unanticipated side effects. Substantial research over the past few decades has elucidated the full range of clinical and resource use effects of peptic ulcer medications, particularly for histamine H 2-receptor antagonists and nonsteroidal anti-inflammatory drug (NSAID)-related gastropathy. Less well known are some of the positive and negative side effects of many different types of pharmaceuticals on the gastrointestinal tract. This paper summarises information on unintended and unexpected positive and negative gastrointestinal side effects of medications administered to treat gastrointestinal and other diseases. It further analyses 2 drug classes and their effects on the gastrointestinal tract, histamine H 2-receptor antagonists, which have a positive impact on clinical effects and resource use, and NSAIDs, which have negative effects.
所有医疗服务无论多么有益，除了护理成本外还存在固有风险，这可能涉及在意外副作用方面的支出。过去几十年的大量研究阐明了消化性溃疡药物的全部临床和资源使用效果，特别是组胺H2受体拮抗剂和非甾体抗炎药（NSAID）相关胃病。许多不同类型药物对胃肠道的一些正面和负面副作用则鲜为人知。本文总结了用于治疗胃肠道及其他疾病的药物意外和意想不到的胃肠道正面和负面副作用的信息。它进一步分析了两类药物及其对胃肠道的影响，组胺H2受体拮抗剂对临床效果和资源使用有积极影响，而NSAIDs则有负面影响。
