Formation of antibodies and immunoglobulins of various classes in persons vaccinated with warm antileptospirosis polyvalent vaccine.

The results of the observations of 2 groups of 372 persons during 10 months showed that a twofold inoculation of corpuscular heated 6-valent antileptospiral vaccine ensures the formation of 19S-antibodies. The ratio 19S/7S antibodies was determined by inactivation of IgM agglutinins with the help of 2-mercaptoethanol. Quantitative content of immunolglobulins (G, A and M) was determined in parallel with the reaction of agglutination by the method of simple radial diffusion. Immunoglobulins of the class M in the serum of vaccinated persons increased as compared with control, whereas the content of IgG did not rise and that of IgA decreased.