Bunin K V, Firsanov V I, Parfenova N N, Kravtsov E G, Nechaeva I P
Zh Mikrobiol Epidemiol Immunobiol. 1976 Sep(9):70-4.
Avidity of specific antibodies was studied in the sera of patients suffering from cholera and vibrio-carriers by the rate of antibody binding (in the bacterial agglutination reaction) and by the completeness of their binding with O-antigen (in the passive hemagglutination test). There were revealed statistically significant higher indices of antibody avidity contained in the blood sera of the vibrio carriers, in comparison with the antibodies in the blood sera of patients with clinically manifest forms of cholera. There proved to be an increase in the antibody avidity in the dynamics of the infectious process. It is supposed that the degree of avidity of anticholera antibodies in examination of whole sera depended on the ratio of the specific macro- and microglobulins in them.
通过抗体结合率（在细菌凝集反应中）以及抗体与O抗原结合的完整性（在被动血凝试验中），研究了霍乱患者和弧菌携带者血清中特异性抗体的亲和力。结果显示，与临床显性霍乱患者血清中的抗体相比，弧菌携带者血清中抗体亲和力的指标在统计学上显著更高。在感染过程中，抗体亲和力有所增加。据推测，在检测全血清时，抗霍乱抗体的亲和力程度取决于其中特异性巨球蛋白和微球蛋白的比例。
