Feĭgin S, Kushnarev V M, Tsvetkova N V, Gromova L A, Vaneeva N P
Zh Mikrobiol Epidemiol Immunobiol. 1976 Sep(9):78-81.
The authors present the results of studying the weakly immunogenic Citrobacter strains; some O-antigens of Citrobacter (11, 14, 19, 21a, 21b, 26) caused in immunization of rabbits a weak immune response (antibody titre--1:400-1:800). An electron microscopic study of the vaccines (obtained from these strains) and their fragments showed that a partial desquamation and denaturing of the antigenic material occurred in the process of preparation of heated vaccines. Formalin-treated vaccine subjected to preliminary deflaggelation for 2 min at 3000 cps was used for obtaining the O-sera against the mentioned antigens.
作者展示了对弱免疫原性柠檬酸杆菌菌株的研究结果；柠檬酸杆菌的一些O抗原（11、14、19、21a、21b、26）在兔免疫中引起了较弱的免疫反应（抗体效价为1:400 - 1:800）。对（由这些菌株制备的）疫苗及其片段进行的电子显微镜研究表明，在加热疫苗的制备过程中，抗原物质发生了部分脱落和变性。经过在3000 cps下初步鞭毛去除处理2分钟的福尔马林处理疫苗，被用于获得针对上述抗原的O血清。
