Mansour A M
Dept. of Ophthalmology, American University of Beirut, Lebanon.
Curr Opin Ophthalmol. 1994 Dec;5(6):105-9. doi: 10.1097/00055735-199412000-00017.
Diode laser photoablation of the retinal periphery is an effective treatment for zone 1 or 2 threshold retinopathy of prematurity. Patients with small cell carcinoma of the lung and cancer-associated retinopathy have immunoreactivity with the 23-kD retinal cancer-associated antigen and a similar antigen is secreted by in vitro propagated cultures of small cell carcinoma of the lung. This cancer-associated autoimmune retinopathy is characterized by rapid visual loss, night blindness, color loss, and reduced electroretinograms. Angioid streaks start as narrow, short discontinuous hypopigmented streaks that enlarge and widen with the end stage being disciform macular degeneration, helicoid peripapillary atrophy, or diffuse choroidal sclerosis. In the setting of neonatal cholestasis, the findings of microcornea, posterior embryotoxon, mosaic iris stromal hypoplasia, anomalous optic discs, and regional peripapillary retinal depigmentation suggest the diagnosis of Alagille syndrome (arteriohepatic dysplasia).
二极管激光光凝视网膜周边部是治疗1区或2区阈值性早产儿视网膜病变的有效方法。小细胞肺癌患者及癌症相关性视网膜病变患者对23-kD视网膜癌相关抗原有免疫反应，且体外培养的小细胞肺癌细胞可分泌一种类似抗原。这种癌症相关性自身免疫性视网膜病变的特征为视力迅速丧失、夜盲、色觉减退及视网膜电图降低。血管样条纹起始为狭窄、短小的不连续色素减退条纹，随后扩大增宽，终末期可出现黄斑盘状变性、视盘周围螺旋状萎缩或弥漫性脉络膜硬化。在新生儿胆汁淤积的情况下，小角膜、后胚胎环、虹膜基质发育不全、视盘异常及视盘周围局部视网膜色素脱失等表现提示阿拉吉尔综合征（动脉肝发育不良）的诊断。
