Bussat A, Langner-Lemercier S, Salmon A, Mouriaux F
Université Rennes, INSERM, INRA, CHU de Rennes, Institut NUMECAN (Nutrition Metabolisms and Cancer), 35000 Rennes, France.
Service de neurologie, CHU de Rennes, 35033 Rennes cedex, France.
J Fr Ophtalmol. 2018 Jun;41(6):554-559. doi: 10.1016/j.jfo.2018.02.003. Epub 2018 Jun 9.
Paraneoplastic syndromes involving the visual system are a heterogeneous group of disorders occurring in the setting of systemic malignancy. Although these syndromes are rare, the clinical manifestations can herald an unsuspected, underlying malignancy. The associated antibodies and histopathology of each syndrome are presented to help in the understanding of these autoimmune phenomena. Outlined in this review article are diagnostic features useful in differentiating cancer-associated retinopathy, melanoma-associated retinopathy, paraneoplastic polymorphous vitelliform maculopathy, bilateral diffuse uveal melanocytic proliferation and paraneoplastic neurologic syndromes such as optic neuropathy, opsoclonus-myoclonus, Lambert-Eaton myasthenia and paraneoplastic cerebellar degeneration.
累及视觉系统的副肿瘤综合征是一组发生于全身恶性肿瘤背景下的异质性疾病。尽管这些综合征罕见,但其临床表现可预示未被怀疑的潜在恶性肿瘤。文中介绍了每种综合征相关的抗体和组织病理学,以帮助理解这些自身免疫现象。这篇综述文章概述了有助于鉴别癌症相关性视网膜病变、黑色素瘤相关性视网膜病变、副肿瘤性多形性卵黄样黄斑病变、双侧弥漫性葡萄膜黑素细胞增生以及副肿瘤性神经综合征(如视神经病变、眼阵挛 - 肌阵挛、兰伯特 - 伊顿肌无力和副肿瘤性小脑变性)的诊断特征。