Dinowitz K, Aldave A J, Lisse J R, Trocme S D
Department of Ophthalmology, University of Texas Medical Branch, Galveston 77550, USA.
Curr Opin Ophthalmol. 1994 Dec;5(6):91-8. doi: 10.1097/00055735-199412000-00015.
Exciting new discoveries into the pathophysiological mechanisms of immunologic and inflammatory ocular disease continue. The genetic locus for susceptibility to Behçet's disease and Sjögrens syndrome has been further characterized. Important guidelines for serial slit-lamp examinations for the early detection of iridocyclitis in juvenile rheumatoid arthritis is suggested. In ocular allergy, further investigation of the interaction between mast cell and eosinophil sheds more light on the pathophysiological mechanism of vernal keratoconjunctivitis and vernal corneal ulcers. Unusual manifestations of Behçet's disease, sarcoidosis, scleritis, and Wegener's granulomatosis are reported. A possible pathophysiological mechanism for lacrimal gland destruction in Sjögrens syndrome is presented.
免疫性和炎性眼病病理生理机制方面令人兴奋的新发现仍在不断涌现。白塞病和干燥综合征易感性的基因位点已得到进一步明确。有人提出了针对幼年类风湿关节炎中虹膜睫状体炎早期检测的系列裂隙灯检查的重要指导原则。在眼部过敏方面，对肥大细胞与嗜酸性粒细胞之间相互作用的进一步研究，为春季角结膜炎和春季角膜溃疡的病理生理机制提供了更多线索。报告了白塞病、结节病、巩膜炎和韦格纳肉芽肿的不寻常表现。提出了干燥综合征中泪腺破坏的一种可能病理生理机制。
