Drózdz M, Kucharz E
Acta Biol Med Ger. 1976;35(7):1023-5.
Guinea pigs were exposed to nitrogen dioxide in concentration of 2 mg/m3 (8 hrs. daily, 180 days). Control group inspired fresh air. Collagen fractions were estimated in skin and assayed as hydroxyproline concentration. An increase of total collagen content, due to on increase of salt-soluble collagen fraction was found in the skin of the exposed animals, while a simultaneous decrease of insoluble collagen content was observed.
将豚鼠暴露于浓度为2毫克/立方米的二氧化氮环境中（每天8小时，共180天）。对照组吸入新鲜空气。测定皮肤中的胶原蛋白组分，并以羟脯氨酸浓度进行分析。结果发现，暴露组动物皮肤中总胶原蛋白含量增加，这是由于盐溶性胶原蛋白组分增加所致，同时观察到不溶性胶原蛋白含量下降。
