Engler E, Matthias D, Herrmann H J, Becker C H
Acta Biol Med Ger. 1976;35(7):983-94.
Daily s.c. injections of 0.02--10.0 mg angiotensin in depot form for 14 days caused in rats, under defined conditions, pronounced dose-dependent effects, with an unusual tolerance to the drug being observed. The behaviour of the systolic and diastolic blood pressure and heart rate allowed to define 4 dose ranges. In the lowest dose range of 0.02 mg angiotensin-II a lasting borderline hypertension with only straight-line changes of diastolic blood pressure and bradycardia were observed. The doses of 0.15--1.25 mg angiotensin-II caused a continual blood pressure rise and led, between day 4 and 6 of the experiment, to a pronounced lasting resistance high-pressure without appreciable changes in heart rate. The strongest resistance high-pressure, which occurred as early as on day 3, with pronounced tachycardia was achieved with a dose of 2.5 mg angiotensin-II. Higher doses produced pronounced tachycardia but no significant effects on blood pressure. The varying dose-dependent effects of depot angiotensin are discussed, and the possibility is pointed out to study by the angiotensin-II hypertension model various mechanisms of a long-time hypertensive dysregulation.
在特定条件下，给大鼠每日皮下注射0.02 - 10.0毫克长效血管紧张素，持续14天，可产生明显的剂量依赖性效应，且观察到大鼠对该药物具有异常耐受性。根据收缩压、舒张压和心率的变化情况可确定4个剂量范围。在最低剂量范围（0.02毫克血管紧张素 - II）时，观察到持续的临界高血压，仅舒张压呈直线变化且伴有心动过缓。0.15 - 1.25毫克血管紧张素 - II的剂量可导致血压持续升高，并在实验第4至6天导致明显的持续性耐药性高血压，心率无明显变化。早在第3天，2.5毫克血管紧张素 - II的剂量可产生最强的耐药性高血压，并伴有明显的心动过速。更高剂量会产生明显的心动过速，但对血压无显著影响。文中讨论了长效血管紧张素不同的剂量依赖性效应，并指出利用血管紧张素 - II高血压模型研究长期高血压失调的各种机制的可能性。
