Matthias D, Wachtel W, Wolf I, Becker C H, Engler E, Herrmann H J
Acta Biol Med Ger. 1976;35(3-4):491-9.
In pigs receiving up to 14 days daily injections of depot angiotensin, repeated daily bloody measurements of the blood pressure at the carotid artery proved unsuitable because of ensueing septic processes, in contrast to the unbloody measurement at the caudal artery. The depot angiotensin, despite the use of preparations with varying content of angiotensin-II and carrier solution, caused immediately after the injections a very strong maximal rise in systolic and diastolic blood pressure that occurred also with longer periods of the experiment; this rise gradually diminished in the course of the day but remained mostly in the hypertonic range and showed daily initial values above normal. The pig proved to be much more sensitive to angiotensin than the rat, for instance. Despite the proved vasoconstricting action of angiotensin, light-microscopic alterations at the vessels, kidneys, and the myocardium could not be observed. Part of the arterioles showed an increased wall thickness in animals killed on the 8th and 15th day of the experiment. The differences in the pathomorphological and blood pressure behaviour from the rat are discussed. The first experimental results qualify the pig as an experimental animal for comparative hypertension studies.
在每天接受长达14天长效血管紧张素注射的猪中，由于随后出现的脓毒症过程，每天重复测量颈动脉血压的有创测量方法被证明不适用，与之形成对比的是尾动脉的无创测量。尽管使用了血管紧张素-II含量和载体溶液不同的制剂，但长效血管紧张素在注射后立即导致收缩压和舒张压非常强烈的最大升高，这种升高在实验较长时间内也会出现；这种升高在一天中逐渐减弱，但大多仍处于高血压范围内，且每日初始值高于正常水平。例如，猪被证明对血管紧张素比大鼠敏感得多。尽管已证实血管紧张素具有血管收缩作用，但在血管、肾脏和心肌的光镜下未观察到改变。在实验第8天和第15天处死的动物中，部分小动脉显示壁厚增加。讨论了与大鼠在病理形态学和血压行为方面的差异。首批实验结果使猪成为用于比较高血压研究的实验动物。
