Kovalyov G V, Tyurenkov I N, Nikolova M, Nikolov R
Acta Physiol Pharmacol Bulg. 1976;2(2):42-8.
The effect of the compound AS2 (N'-benzhydryl, N''-allylpiperazine dihydrochloride) on the central and peripheral mechanisms of vascular tone regulation is studied. Six series of experiments on cats are carried out. The effect of the compound is tested on a model of central-hypertensive reaction, on the spontaneous bioelectrical activity of the renal nerve, on the transmission of excitation to the upper cervical ganglion and the ganglia of the solar plexus. Experiments are made to study its adrenolytic a-d myotropic properties. Cinnarizine is tested as control. The results show that the compound AS2, similar to Cinnarizine, affects the central and peripheral mechanisms of vascular tone regulation. In small doses (1-5 mg/kg) AS2 manifests poor myotropic properties. Administration of the drug in doses of 10-20 mg/kg results in considerable inhibition of the vasomotor centres, brief disturbances in the excitation transmission in the sympathetic ganglia and slight inhibition of adrenergic transmission.
研究了化合物AS2（N'-二苯甲基，N''-烯丙基哌嗪二盐酸盐）对血管张力调节的中枢和外周机制的影响。对猫进行了六组实验。测试了该化合物对中枢性高血压反应模型、肾神经自发生物电活动、兴奋向上颈神经节和太阳神经丛神经节传递的影响。进行实验以研究其抗肾上腺素能α-d肌otropic特性。以桂利嗪作为对照进行测试。结果表明，化合物AS2与桂利嗪相似，影响血管张力调节的中枢和外周机制。小剂量（1-5毫克/千克）的AS2表现出较差的肌otropic特性。以10-20毫克/千克的剂量给药该药物会导致血管运动中枢受到相当大的抑制，交感神经节兴奋传递出现短暂紊乱，以及肾上腺素能传递受到轻微抑制。
