Kovalev G V, Tiurenkov I N
Farmakol Toksikol. 1977 May-Jun;40(3):313-7.
Acute experiments with anesthetized and decerebrate cats brought evidence that in a dose of 1 mg/kg apressin first increases by 50 per cent the centrogenically-produced pressor vascular reactions and then (30-60 min thereafter) suppresses pressor responses. Apressin (in a dose of 3-5 mg/kg) appreciably weakens the intensity of the pressor vascular reactions and increases the efferent outflow in the renal nerve. In doses of 1-10 mg/kg it does not affect the transmission of excitation in the superior cervical sympathic ganglion and in the solar plexus nodes. In tests with the crossed circulation apressin in doses of 1 and 5 mg/kg produces a marked depression of vascular reactions and a drop of the perfusion pressure in the vessels of the hind extremity perfused with the autoblood and a rising intensity of these reactions along with a greater resistance of the hind extremity vessels, perfused with the donor's blood.
对麻醉和去大脑猫进行的急性实验表明，剂量为1毫克/千克的垂体后叶加压素首先使中枢源性产生的加压血管反应增加50%，然后（此后30 - 60分钟）抑制加压反应。垂体后叶加压素（剂量为3 - 5毫克/千克）明显减弱加压血管反应的强度，并增加肾神经的传出冲动。剂量为1 - 10毫克/千克时，它不影响颈上交感神经节和太阳神经丛节中兴奋的传递。在交叉循环试验中，剂量为1和5毫克/千克的垂体后叶加压素会使血管反应明显减弱，使灌注自身血液的后肢血管灌注压下降，而使灌注供血者血液的后肢血管反应强度增加，同时后肢血管阻力增大。
