Radomirov R
Acta Physiol Pharmacol Bulg. 1976;2(2):58-62.
In certain methodological setups the pharmacological agent is applied in a flowing fluid and washes the smooth-muscle preparation for a certain period of time. In such cases it is possible to observe differences in the slope of the curves of the contractile and relaxation phases of the contraction and appearance of the amplitude maximum at different moments in the total duration of the contractile process. The recording of the average development rates of the contraction phases, in addition to the commonly accepted indicator of th effect of the amplitude maximum, could give an additional characteristic to the action of the pharmacological substances. A method is proposed for determination of the average rates of the contractile and relaxation phases, as well as the relative dependence between them.
在某些方法学设置中，将药理剂应用于流动的液体中，并在一定时间内冲洗平滑肌制剂。在这种情况下，有可能观察到收缩过程总持续时间内不同时刻收缩和舒张相曲线斜率的差异以及最大振幅的出现情况。记录收缩相的平均发展速率，除了常用的最大振幅效应指标外，还可为药理物质的作用提供一个额外的特征。本文提出了一种测定收缩相和舒张相平均速率以及它们之间相对依赖性的方法。
