Kosterin S A, Burdyga F V
Biofizika. 1990 Mar-Apr;35(2):350-5.
A method is proposed for analysing kinetic curves of the smooth muscle contraction--relaxation approved on smooth muscle preparations of ureter and taenia coli. A notion of the velocity coefficient is introduced. It is the parameter which gives a quantitative characteristics of changes in the dynamics of muscle contraction and relaxation under the effect of factors modifying the contractile response. In order to illustrate the application of this parameter studies were carried out of the effect of sodium-free medium, monensin, and of temperature decrease on the contractile activity of the smooth muscle tissue of the ureter. The method can be useful while investigating the regularities of electro- and pharmacomechanical conjunction in the smooth muscles, as well as during pharmacological screening of compounds--regulators of calcium homeostasis in myocytes and their contractile activity.
本文提出了一种分析输尿管和结肠带平滑肌制剂上平滑肌收缩 - 舒张动力学曲线的方法。引入了速度系数的概念。它是一个参数，用于定量表征在改变收缩反应的因素作用下肌肉收缩和舒张动力学的变化。为了说明该参数的应用，研究了无钠培养基、莫能菌素以及温度降低对输尿管平滑肌组织收缩活性的影响。该方法在研究平滑肌电 - 机械和药理 - 机械偶联规律时，以及在对化合物（心肌细胞钙稳态调节剂及其收缩活性）进行药理筛选时可能会有用。
