一份关于伴有多发性皮肤癌的皮肤病——疣状表皮发育不良的病例报告，包括电镜检查和DNA修复研究。

A case report including EM and DNA repair investigations in a dermatosis associated with multiple skin cancers: epidermodysplasia verruciformis.

作者信息

Hammar H, Hammar L, Lambert L, Ringborg U

出版信息

Acta Med Scand. 1976;200(6):441-6. doi: 10.1111/j.0954-6820.1976.tb08261.x.

DOI:10.1111/j.0954-6820.1976.tb08261.x

Abstract

This report describes the clinical, histological and electron microscopic observations in a 51-year-old male with epidermodysplasia veruciformis (EV). Cells with early signs of malignant transformation were found closely connected with virus infected epidermal regions. Skin cancers appeared initially on sun-exposed areas, such as the face and ear lobes. The UV-induced DNA repair synthesis was therefore studied, utilizing peripheral leukocytes. The patient had 40% lower UV-induced DNA repair synthesis than the mean of nine healthy subjects of the same age. These results suggest that a decrease in UV-induced DNA repair synthesis in combination with a possibly oncogenic viral infection may enhance the disposition for somatic mutations and malignant transformation in patients with EV.

摘要

本报告描述了一名51岁疣状表皮发育不良（EV）男性患者的临床、组织学和电子显微镜观察结果。发现具有早期恶性转化迹象的细胞与病毒感染的表皮区域紧密相连。皮肤癌最初出现在面部和耳垂等阳光暴露部位。因此，利用外周血白细胞研究了紫外线诱导的DNA修复合成。该患者紫外线诱导的DNA修复合成比九名同龄健康受试者的平均值低40%。这些结果表明，紫外线诱导的DNA修复合成减少，再加上可能致癌的病毒感染，可能会增加EV患者发生体细胞突变和恶性转化的倾向。