脑线粒体的代谢及死后电子显微镜研究。

Metabolic and electron microscopic studies post mortem in brain mitochondria.

作者信息

Ikrényi K, Dóra E, Hajós F, Kovách A G

出版信息

Adv Exp Med Biol. 1976;75:159-64. doi: 10.1007/978-1-4684-3273-2_20.

Abstract

The RCR of malate+glutamate oxidation of isolated rat brain mitochondria decreased with increasing duration of anoxia and it ceased completely in the 12 hour ischemic group. After one hour of ischemic anoxia neither the respiration of mitochondria nor their morphology altered irreversibly. There is a strong correlation between the ultrastructural changes and RCR value of mitochondria, namely the RCR decreased proportionally with increasing number of light type of mitochondria. From our results we can conclude that the dense form seems to be the functional form, while the light mitochondrial structure is a transition to the non functioning homogenous type of brain mitochondria.

摘要

离体大鼠脑线粒体苹果酸+谷氨酸氧化的呼吸控制率（RCR）随着缺氧时间的延长而降低，在缺血12小时组中完全消失。缺血缺氧1小时后，线粒体的呼吸及其形态均未发生不可逆改变。线粒体的超微结构变化与RCR值之间存在很强的相关性，即RCR随着轻型线粒体数量的增加而成比例降低。从我们的结果可以得出结论，致密型似乎是功能型，而轻型线粒体结构是向无功能的均质型脑线粒体的转变。