Shah J P, Cendon R A, Farr H W, Strong E W
Am J Surg. 1976 Oct;132(4):504-7. doi: 10.1016/0002-9610(76)90328-7.
A retrospective review of the clinical records of patients with carcinoma of the oral cavity was undertaken, and several parameters were studied in terms of comparing two groups of patients: those who were controlled at the primary site and neck and others who failed locally or regionally following initial treatment. A comparative statistical analysis of the factors studied revealed that female patients who had a higher T status, a higher N status, and thus a higher stage of disease did poorly in terms of local and regional control of disease. Those patients whose primary tumors manifested deep invasion and those who had positive margins after surgical resection at the primary site had also a significantly high incidence of local/regional failure. Presence of extracapsular extension of disease in cervical lymph nodes and involvement of soft tissues in the neck as well as involvement of multiple lymph nodes at multiple levels also put the patients in a high risk category. We urge that these factors be considered as prognostic criteria and be used to select patients for treatment by additional modalities on an elective basis in hope of achieving better local and regional control of disease and perhaps better cure rates.
对口腔癌患者的临床记录进行了回顾性研究，并就两组患者进行了若干参数的比较：一组是原发部位和颈部得到控制的患者，另一组是初始治疗后局部或区域治疗失败的患者。对所研究因素的比较统计分析显示，T分期较高、N分期较高从而疾病分期较高的女性患者在疾病的局部和区域控制方面表现较差。原发肿瘤表现为深度浸润的患者以及原发部位手术切除后切缘阳性的患者，其局部/区域失败的发生率也显著较高。颈部淋巴结存在包膜外扩散、颈部软组织受累以及多个层面的多个淋巴结受累也使患者处于高风险类别。我们敦促将这些因素视为预后标准，并用于选择性地选择患者进行额外的治疗方式，以期实现更好的疾病局部和区域控制，或许还能提高治愈率。
